Where to begin when touching up a photo?

i have old photo (from u.s. civil war, i.e., old) need touch up. printed eventually. need know best order in perform various operations.

it tiff, 105mb, 40 inches square, 700 ppi, 16-bit black , white.

what need reduce size 17 inches 300 ppi, clean cracks , spots in photo, sharpen face of 1 person little out of focus, play lighting bring out little more detail , finally, turn duotone.

and, of course, non-destructively can make changes in future.

i know how these operations, in order best?

i have gone ahead clean cracks , spots while photo @ huge size , resolution. reduced size , resolution. done "destructively." (of course still have original).

it seems me last thing do make duotone because, in order so, have make 8-bit grayscale, thereby loosing detail. should last thing , can make multiple duotones.

is right? , best order sharpening , highlight/contrast? use adjustment layers not destroy pixels.

further, there way create dutone using adjustment layers?

lot of questions! suggestions appreciated.

thanks,
tom

first of all, still have access original photo?

if so, scan again target size want printing. you'll much, better results if downsample monster scan you've got right now.

>a tiff, 105mb, 40 inches square, 700 ppi,

have right whopping 28,000x28,000 pixels image.

all need 5,100 x 5,100 pixels print 17 inches 300 ppi.

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